aa149
trepibutone
CAS: 41826-92-0
Molecular Formula: C16H22O6
aa149 - Names and Identifiers
| Name | trepibutone |
| Synonyms | aa149 colibil supacal aa149 colibil supacal trepibutone Trepibutone TREPIBUTONE 3-(2,4,5-triethoxybenzoyl)-propionicaci 3-(2,4,5-triethoxybenzoyl)propionicacid 3-(2,4,5-triethoxybenzoyl)propionicacid 3-(2,4,5-triethoxybenzoyl)-propionicaci 4-oxo-4-(2,4,5-triethoxyphenyl)butanoic acid 4-Oxo-4-(2,4,5-triethoxyphenyl)butanoic acid 2,4,5-triethoxy-gamma-oxobenzenebutanoicacid 2,4,5-triethoxy-gamma-oxobenzenebutanoicacid |
| CAS | 41826-92-0 |
| InChI | InChI=1/C16H22O6/c1-4-20-13-10-15(22-6-3)14(21-5-2)9-11(13)12(17)7-8-16(18)19/h9-10H,4-8H2,1-3H3,(H,18,19) |
aa149 - Physico-chemical Properties
| Molecular Formula | C16H22O6 |
| Molar Mass | 310.34 |
| Density | 1.1625 (rough estimate) |
| Melting Point | 150-151° |
| Boling Point | 370.51°C (rough estimate) |
| Flash Point | 179.9°C |
| Vapor Presure | 9.27E-11mmHg at 25°C |
| pKa | 4.40±0.17(Predicted) |
| Storage Condition | RT, dark |
| Refractive Index | 1.4600 (estimate) |
| Physical and Chemical Properties | Properties: yellowish crystal or crystalline powder, odorless, soluble in chloroform, slightly soluble in ethanol, almost insoluble in water, soluble in sodium hydroxide solution. |
| Use | For cholagogue and lithagogue |
aa149 - Reference Information
| introduction | qupibutong is also known as danling, danyining, shudantong, triether butyric acid, triethyl butanone, triethoxybenzoyl propionic acid. The substance is white or yellowish crystalline powder, easy to tolerate in chloroform, soluble in methanol, almost insoluble in water. |
| indications | trepibutone is suitable for cholelithiasis, cholecystitis, biliary dyskinesia, gallbladder postoperative syndrome and chronic pancreatitis. |
| adverse reactions | (1) digestive system: occasional symptoms such as nausea, vomiting, lack of appetite, excessive saliva secretion, stomach discomfort, abdominal distension, diarrhea and constipation. (2) allergy: occasional rash, itching, etc. (3) Others: Occasionally dizziness, head weight, and burnout. |
| pharmacological action | tropibuton is a non-anticholinergic biliary smooth muscle relaxant, which can promote bile secretion and has strong antispasmodic and analgesic effects. After oral administration, it is quickly absorbed from the gastrointestinal tract, mainly distributed in the intestine, liver, kidney, gallbladder, and pancreas. In liver metabolism, the main metabolites are glucuronic acid conjugates and dealkylphenols. Its plasma half-life is 1.5~2 hours. |
| pharmacokinetics | tripbuton was rapidly absorbed from gastrointestinal tract after oral administration, and the blood drug concentration reached a peak value after a single oral administration of this drug for 30-60min in healthy adult men and women. Mainly distributed in the intestine, liver, kidney, gallbladder, pancreas. In liver metabolism, the main metabolites are glucuronic acid conjugates and dealkylphenols. The half-life of plasma is 1.5-2h, and it completely disappears from plasma for about 6h. Within 24h, it is excreted from kidney and bile in the form of metabolites and a small part of the drug (70% is excreted from urine, 54% in urine is glucuronic acid conjugate, 11% is dealkylphenol, and 5% is excreted as the original drug; The ratio of glucuronic acid conjugate excreted in bile to the original drug is about 7:3, other metabolites are below the detectable limit). Patients with T-tube after gallbladder removal accelerated their bile excretion. After oral administration of this drug for 2-4h, the concentration in bile reached the highest peak, and then disappeared from bile for about 10h. |
| use | for choleretic stone removal |
Last Update：2024-04-10 22:29:15
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